Lymphocyte subsets in lung cancer detected by monoclonal antibodies.

THE PRODUCTION OF MURINE MONOCLONAL ANTIBODIES (MAb) DIRECTED AGAINST HUMAN T- LYMPHOCYTE SUBSETS

The production of murine monoclonal antibody (MAb) has not yet been reported in Iran. The present work describes for the first time the generation of several murine hybridoma clones secreting MAbs directed against human leukocyte surface antigens. The secreted antibodies by hybridoma clones have been screened on different lymphoid and non-lymphoid tissues. Results indicated that of seven h...

Monoclonal antibodies in lung cancer.

Human pancreatic cancer-associated antigens detected by murine monoclonal antibodies.

Two monoclonal antibodies, YPan1 and YPan2, were produced from spleen cells of mice immunized against a human pancreatic cancer cell line, Capan-2, which also reacted with eight other human pancreatic carcinoma cell lines and with sections of cancerous human pancreas tissue. Reactivity was also found with colonic and stomach carcinoma tissues. Whereas YPan1 reacted strongly with normal pancreat...

Carbohydrate differentiation and cancer-associated antigens detected by monoclonal antibodies.

action was the pluripotential haemopoietic stem cell (CFUS ) . Whenever they were tested, free glycosaminoglycan chains were unable to reproduce P-D-xyloside influences on cell behaviour. On the basis of the cited biochemical evidence it seems likely that the xyloside effects are mediated through alterations in surface membrane proteoglycans. Most probably the xyloside-induced changes follow fr...

Human mast cells detected by monoclonal antibodies.

We report the establishment of seven mouse-mouse hybridoma cell lines secreting monoclonal antibodies with specificity for granule components of all human mast cells. Reactivity is directed against a molecule which is also found intracytoplasmically in human mature small intestinal enterocytes, liver parenchymal cells, and kidney proximal tubule epithelial cells. No reactivity of these antibodi...